Genome-Wide Association Study Identifies a New Locus JMJD1C at 10q21 That May Influence Serum Androgen Levels in Men

A genome-wide association study (GWAS) involving 3225 men of European ancestry from the REDUCE study identified a new genetic locus, JMJD1C at 10q21, associated with serum testosterone (T) levels. This study confirmed the associations of two previously known loci, SHBG at 17p13 and FAM9B at Xp22, with serum T levels and found that the SHBG locus was also associated with serum dihydrotestosterone (DHT) levels. The identified loci (JMJD1C, SHBG, and FAM9B) accounted for approximately 5.3% and 4.1% of the variance in serum T and DHT levels, respectively, providing new insights into the genetic regulation of circulating androgens and potential targets for androgen-based therapy.