Treatment With Ashwagandha-Derived Exosome-Like Nanovesicles Up-Regulates VEGF-A Production and Promotes Human Hair Growth Ex Vivo

    July 2026 in “ Experimental Dermatology ”
    Alizée Le Riche, Janina Nienhaus, Marta Silva e Sousa … Giorgio Dell’Acqua
    Studysummary This study found that Ashwagandha-derived exosome-like nanovesicles promoted hair growth in several preclinical models and may offer a novel non-drug strategy to reduce hair shedding.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 24

    1. Iris Germanica L. Rhizome-Derived Exosomes Ameliorated Dihydrotestosterone-Damaged Human Follicle Dermal Papilla Cells Through the Activation of Wnt/β-Catenin Pathway International Journal of Molecular Sciences · 2025
    2. Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: Current Progress and Future Perspectives International journal of nanomedicine · 2024
    3. Revealing Novel Insights on How Oral Supplementation With Collagen Peptides May Prevent Hair Loss: Lessons From the Human Hair Follicle Organ Culture Journal of functional foods · 2024
    4. Effectiveness of a Novel Compound Hair and Scalp Complex on Hair Follicle Regeneration Cosmetics · 2024
    5. Effects of Withania Somnifera Root Extract Serum Application on Hair Health in Healthy Adults: A Prospective, Double-Blind, Randomized, Parallel, Placebo-Controlled Study Journal of Ayurveda and Integrative Medicine · 2023
    6. Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions Journal of Nutrition and Metabolism · 2023
    7. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    8. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    9. Role and Mechanisms of Phytochemicals in Hair Growth and Health Pharmaceuticals · 2023
    10. Efficient Establishment of an Optimized Culture Condition for Cashmere Goat Primary Hair Follicle Stem Cells Journal of animal science/Journal of animal science ... and ASAS reference compendium · 2023
    11. Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo Cells · 2022
    12. Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype Nutrients · 2022
    13. An Extract of Leontopodium Alpinum Inhibits Catagen Development Ex Vivo and Increases Hair Density In Vivo International Journal of Cosmetic Science · 2022
    14. Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration Applied Materials Today · 2020
    15. Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore, Improves Telogen Effluvium-Associated Parameters Journal of Cosmetic Dermatology · 2020
    16. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019
    17. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    18. Hypoxia Improves Hair Inductivity of Dermal Papilla Cells via Nuclear NADPH Oxidase 4-Mediated Reactive Oxygen Species Generation British Journal of Dermatology · 2019
    19. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    20. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    21. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    22. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    23. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    24. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001