Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions

    September 2023 in “ Journal of Nutrition and Metabolism ”
    Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Rahul Chatterjee
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    TLDR One Ashwagandha extract may help protect cells with its antioxidant properties, while another could promote hair growth.
    The research paper studied two Ashwagandha extracts, ASH-Ext1 and ASH-Ext2, with different withanolide proportions. ASH-Ext1 was found to support antioxidant activity and Nrf2 signaling modulation in various cell models, demonstrating higher antioxidant activity and cytoprotection efficacy compared to a commercial Ashwagandha extract. ASH-Ext2 increased β-catenin and telomerase reverse transcriptase (TERT) protein expression levels in human hair follicle dermal papilla cells (HFDPCs), crucial for hair formation and cycling. The study concluded that Ashwagandha extracts have potential therapeutic benefits, including hair growth promotion, but emphasized the need for standardization in the extraction process for consistent pharmacological outcomes.
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