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    Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions

    September 2023 in “ Journal of Nutrition and Metabolism ”
    Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule … Rahul Chatterjee
    Studysummary This study found that the ashwagandha extracts ASH-Ext1 and ASH-Ext2 show different pharmacological activities in cell models due to their distinct withanolide proportions, highlighting the need for standardized extraction protocols to ensure consistent therapeutic efficacy.
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    Research cited in this study 7

    1. Editorial: Hair Follicle Stem Cell Regeneration in Aging Frontiers in Cell and Developmental Biology · 2021
    2. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    3. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    4. Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling Molecular therapy · 2017
    5. Activating Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Increases Hair Inductivity FEBS Journal · 2016
    6. Human TSC2-Null Fibroblast-Like Cells Induce Hair Follicle Neogenesis and Hamartoma Morphogenesis Nature Communications · 2011
    7. Effects of Immunosuppressive Peptidyl-Prolyl Cis-Trans Isomerase (PPIase) Inhibitors, Cyclosporin A, FK506, Ascomycin, and Rapamycin, on Hair Growth Initiation in Mice: Immunosuppression Is Not Required for New Hair Growth Journal of Dermatological Science · 1995