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    Glossary Intermediate Filaments

    structural proteins in cells providing mechanical support and stability

    Intermediate filaments are a type of structural protein found within cells that help maintain their shape and integrity. They are part of the cytoskeleton, which also includes microtubules and actin filaments, and they provide mechanical support to cells, enabling them to withstand stress and strain.

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    1. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament Genomics · 2007 · 27 citations
    2. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    3. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    4. Complete sequence of a hair-like intermediate filament type II keratin gene DNA sequence · 1993 · 15 citations
    5. A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001 · 41 citations
    6. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    7. Role of human type II hair keratins in intermediate filament bundling in vitro 2015
    8. Three-dimensional modelling of interchain sequence similarities and differences in the coiled-coil segments of keratin intermediate filament heterodimers highlight features important in assembly Journal of Structural Biology · 2007 · 13 citations
    9. Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein Biomacromolecules · 2012 · 51 citations
    10. Structural Stability of Wild Type and Mutated α-Keratin Fragments:  Molecular Dynamics and Free Energy Calculations Biomacromolecules · 2004 · 40 citations
    11. A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform Journal of Biological Chemistry · 1997 · 28 citations
    12. <i>In vitro</i> Assembly Properties of Human Type I and II Hair Keratins Cell structure and function · 2014 · 12 citations
    13. The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties Journal of Biological Chemistry · 1998 · 46 citations
    14. Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target 2019 · 4 citations
    15. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments 2000 · 91 citations
    16. Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice Journal of Biological Chemistry · 2014 · 15 citations
    17. High-sulfur protein deficient human hair: clinical aspects and biochemical study of two unreported cases of a variant type of trichothiodystrophy 1989 · 11 citations
    18. Skin Keratins 2015 · 54 citations
    19. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    20. Proteopedia entry: Coiled‐coil structure of keratins Biochemistry and Molecular Biology Education · 2013 · 10 citations
    21. Keratins: Dynamic, flexible structural proteins of epithelial cells Current problems in dermatology · 2001 · 13 citations
    22. Construction and Verification of Recombinant Follicle-specific Expression Vector Anhui nongye kexue · 2011
    23. Against the Rules: Human Keratin K80 Journal of Biological Chemistry · 2010 · 40 citations
    24. Sequence and expression of human hair keratin genes Journal of Dermatological Science · 1994 · 19 citations
    25. Evolution of Trichocyte Keratins Advances in experimental medicine and biology · 2018 · 18 citations
    26. Genes for intermediate filament proteins and the draft sequence of the human genome Journal of Cell Science · 2001 · 287 citations
    27. Isolation of intermediate filament assemblies from human hair follicles. The Journal of Cell Biology · 1985 · 28 citations
    28. Annotation of sheep keratin intermediate filament genes and their patterns of expression Experimental Dermatology · 2011 · 83 citations
    29. In vivo formation steps of the hard α-keratin intermediate filament along a hair follicle: Evidence for structural polymorphism Journal of Structural Biology · 2006 · 22 citations
    30. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations