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    Did you mean Transgenic Mouse Model?
    Glossary Transgenic Mouse Model

    A transgenic mouse model is a genetically modified organism that has had a foreign gene inserted into its genome, allowing researchers to study the effects of specific genes on biological processes, including hair loss and hair biology. These models are particularly relevant in the field of hair research as they can mimic human hair loss conditions, such as androgenetic alopecia or alopecia areata, providing insights into the underlying mechanisms and potential therapeutic targets. Key distinguishing characteristics of transgenic mouse models include the ability to control gene expression and the capacity to observe phenotypic changes in hair growth and follicle development in a living organism.

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    1. Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions Experimental dermatology · 2000 · 20 citations
    2. Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris Journal of Dermatological Science · 2011 · 17 citations
    3. K6/ODC transgenic mice as a sensitive model for carcinogen identification Toxicology Letters · 2000 · 57 citations
    4. Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis Molecular Carcinogenesis · 2006 · 7 citations
    5. Transgenic mouse models support HCR as an effector gene in the PSORS1 locus 2004 · 37 citations
    6. Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics Journal of Investigative Dermatology · 2014 · 16 citations
    7. Animal Models of Psoriasis – What Can We Learn from Them? Journal of Investigative Dermatology · 1999 · 127 citations
    8. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update Journal of Dermatological Science · 2012 · 52 citations
    9. Evaluation of Animal Models Suitable for Hair Research and Regeneration InTech eBooks · 2018 · 3 citations
    10. Experimental Models and Molecular Pathogenesis: An Integrated Review of Alopecia Dermatologic Therapy · 2026
    11. Alopecia areata − animal models Clinical and Experimental Dermatology · 2002 · 69 citations
    12. A Review of Hair Anatomy and Animal Models for Alopecia Recent Trends in Pharmaceutical Sciences and Research · 2023
    13. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 380 citations
    14. Visualising Androgen Receptor Activity in Male and Female Mice PloS one · 2013 · 89 citations
    15. 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function Journal of Investigative Dermatology · 2017
    16. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. PubMed · 2000 · 99 citations
    17. Development of Heritable Melanoma in Transgenic Mice Journal of Investigative Dermatology · 1998 · 75 citations
    18. Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature 2020 · 15 citations
    19. Inducible, reversible hair loss in transgenic mice. Transgenic Research · 2002 · 3 citations
    20. 607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice Journal of Investigative Dermatology · 2021
    21. Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069. PubMed · 2002 · 143 citations
    22. Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells heiDOK (Heidelberg University) · 2012
    23. The Effects of Induced Polycystic Ovary Syndrome in NAG-1 Transgenic Mice ScholarWorks (Central Washington University) · 2020
    24. Transduction‐induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma‐like phenotype Experimental dermatology · 2021 · 5 citations
    25. Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing PLOS ONE · 2012 · 23 citations
    26. A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis Cell stem cell · 2021
    27. Role of bulge cells in wound healing: possible implications for hidradenitis suppurativa Experimental dermatology · 2006
    28. Hair transplantation in mice: Challenges and solutions Wound Repair and Regeneration · 2016 · 3 citations
    29. Transgenic HPV11-E2 protein modulates URR activity in vivo Transgenic Research · 2023 · 2 citations
    30. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010 · 42 citations