130 citations
,
February 2005 in “Proceedings of the National Academy of Sciences” This study found that differentiated cells of the corneal epithelium can be converted to hair and interfollicular epidermis through a multistep process involving dermal developmental signals.
55 citations
,
January 2004 in “The International Journal of Developmental Biology” This study reports that corneal transient amplifying cells can be reprogrammed into epidermal cells capable of forming hair follicles in response to embryonic dermis signals.
15 citations
,
January 2015 in “Stem cells international” This study found that erythrocytes can be generated from human hair follicle mesenchymal stem cells with OCT4 expression, potentially serving as an alternative source for transfusions.
January 2008 in “Di-san junyi daxue xuebao” This study found that hair follicle stem cells from young rats can be induced in vitro to differentiate into corneal epithelium-like cells using homogenate of rabbit corneal limbal stroma.
44 citations
,
March 2008 in “Journal of Experimental Botany” This study found that during bark regeneration after girdling, immature xylem cells can transdifferentiate into phloem cells, with exogenous indole acetic acid accelerating this process.
1 citations
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June 2014 in “Journal of developmental biology” This study found that retinoic acid induces epidermal transdifferentiation into mucosal epithelium in both chick and mammalian embryonic skin, involving specific gene expressions and pathways.
January 2004 in “Linchuang pifuke zazhi” In this study, all-trans retinoic acid was found to promote differentiation and inhibit proliferation of amelanotic melanocytes from human hair follicles, suggesting a potential role in melanogenesis.
24 citations
,
December 2016 in “Stem Cell Research & Therapy” This study found that P311 triggers transdifferentiation of epidermal stem cells into myofibroblast-like cells via TGFβ1/Smad signaling during wound healing.
20 citations
,
April 2009 in “Cell Biology International” This study demonstrates that bulge KSCs from hair follicles can transdifferentiate into corneal epithelial-like cells under specific conditions, which could support bioengineered cornea development.
4 citations
,
September 2024 in “Development” This study investigated transcription factors in human trophectoderm cells during development, finding that GATA2 and GATA3 are essential for transforming stem cells into induced trophoblast stem cells, which display characteristics similar to placental progenitor cells, offering new methods for modeling placental-associated diseases.
September 2008 in “Acta Ophthalmologica” This study found that murine vibrissa hair follicle stem cells can differentiate into corneal epithelial-like cells in vitro when cultured with limbus-specific microenvironmental factors.
162 citations
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December 2008 in “Stem Cells” This study found that murine vibrissa hair follicle stem cells can be differentiated into corneal epithelial-like cells in vitro using limbus-specific microenvironmental factors, suggesting a potential therapeutic source for ocular surface disorders.
26 citations
,
April 2012 in “PubMed” In this study, myofibroblasts in rat cutaneous fibrosis were characterized by expressions of vimentin, α-SMA, and Thy-1, and may derive from pericytes or perifollicular dermal sheath cells.
14 citations
,
January 2011 in “The International Journal of Developmental Biology” This study showed that coexpression of TG2 and Gbx1 in the epidermis is necessary for esophagus-like mucosal transdifferentiation, with TGF-beta2 in the dermis essential for the process through epithelial-mesenchymal interaction.
This study found that administering gingerol improved survival and reduced organ damage in mouse models of chronic graft-versus-host disease by modulating T cell differentiation and inflammatory cytokines, suggesting a novel therapeutic approach for steroid-refractory cases.
41 citations
,
October 2019 in “Biomolecules” This review highlights the role of all-trans retinoic acid in regulating stem and progenitor cell proliferation and differentiation, suggesting its potential to enhance treatments in regenerative medicine and cancer.
22 citations
,
June 2020 in “iScience” This study found that disrupting Sox21 in developing teeth leads to severe enamel hypoplasia, regional osteoporosis, and abnormal hair formation, with impaired dental epithelial differentiation and regulation of hair follicle cell fate.
19 citations
,
January 2013 in “Frontiers in Neuroanatomy” This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.
January 2025 in “International Journal of Molecular Sciences” This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.
This study demonstrated that a ligand-independent action of the vitamin D receptor significantly affects keratinocyte behavior in hair follicles and skin, pointing to its crucial role in maintaining normal hair and skin structures in rats.
160 citations
,
January 2017 in “Development” This study found that hypertrophic chondrocytes at the fracture callus border may convert to osteoblasts, influenced by vasculature and pluripotency gene expression.
139 citations
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August 2018 in “Development” This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.
June 2018 in “Biomedical Journal of Scientific & Technical Research” This mini review discusses cellular plasticity in cutaneous wound healing and reports no clinical results; the authors aim to enhance regenerative medicine by examining underlying mechanisms.
64 citations
,
August 2013 in “Mayo Clinic Proceedings” This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.
January 2023 in “Journal of cosmetic dermatology” This study found that the synthetic retinoid EC23 effectively induces keratinocyte hyperproliferation and enhances hair growth in mice, showing more potency than all-trans retinoic acid.
40 citations
,
December 2015 in “Stem Cells International” This review discusses the roles that mesenchymal stem cells may play in reepithelialization of wounds, but reports no new clinical results.
9 citations
,
March 2013 in “Expert opinion on biological therapy” This article reviews recent research on adult epidermal stem cells, discussing their properties and potential for reprogramming into patient-specific therapies, and emphasizes the need for further development while minimizing cancer risk.
January 2025 in “Frontiers in Cell and Developmental Biology” This study explored the molecular mechanisms determining the identity of keratinocytes and corneal epithelial cells, finding that miRNAs from the Gtl2-Dio3 region, which regulate key signaling pathways, play a significant role in cell identity through the Hox/Gtl2-Dio3 miRNA axis.
July 2020 in “Research Square (Research Square)” This study found that a 3D co-culture of adipose-derived stem cells and endothelial colony forming cells restored stem cell properties and enhanced wound healing in a mouse model.
June 2026 in “Journal of Investigative Dermatology” Retinoic acids temporarily change skin stem cells to a slower cycle and more differentiated state.