Transdifferentiation of Rat Hair Follicle Stem Cells to Epithelium-Like Cells Induced by Stroma of Limbus Corneae

    January 2008 in “ Di-san junyi daxue xuebao ”
    Ke Yang
    TLDR Rat hair follicle stem cells can become corneal epithelium-like cells when exposed to rabbit corneal limbal stroma.
    The study investigated the potential for hair follicle stem cells from 7-to 8-day-old SD rats to differentiate into epithelium-like cells when induced by rabbit corneal limbal stroma. The researchers found that these stem cells, which expressed α 6-integrin and CD34, could be induced to express Keratin-12 (K12) after 10 days, as confirmed by immunocytochemistry and RT-PCR. Flow cytometry also showed a significant rate of K12-positive cells, indicating successful differentiation into corneal epithelium-like cells in vitro.
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