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Research

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research Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss

January 2008 in “Journal of Clinical Dermatology”

This study found that integrin alpha-6 and p63 may play a role in hair loss, with variable expression patterns in different types of alopecia observed in scalp biopsy samples.

research Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin

5 citations , May 2023 in “Frontiers in Cell and Developmental Biology”

This study used single-cell techniques and lineage tracing to reveal that integrin α6 expression in neural crest cells can differentiate them into Schwann cells, melanocytes, and fibroblasts in skin, identifying integrin α6 as a potential marker for these derivatives.

research Delta‐6 desaturase knockout mouse illustrates previously undocumented pathology

1 citations , April 2007 in “The FASEB Journal”

In this study, D6D knockout mice showed severe deficiency in AA and DHA, leading to unexpected effects on skin health, fertility, and immune cell development.

research Abstract 5216: Impact of Stat3 deletion or activation on keratinocyte stem/progenitor cells

April 2012 in “Cancer Research”

This study found that Stat3 influences the differentiation and migration of keratinocytes, potentially impacting epithelial carcinogenesis, by examining Stat3 activation or deletion effects in mouse models.

research Transdifferentiation of rat hair follicle stem cells to epithelium-like cells induced by stroma of limbus corneae

January 2008 in “Di-san junyi daxue xuebao”

This study found that hair follicle stem cells from young rats can be induced in vitro to differentiate into corneal epithelium-like cells using homogenate of rabbit corneal limbal stroma.

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Community Join

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community Should you stop finasteride if you're trying to conceive?

40 upvotes 1 month ago

Stopping finasteride 3 to 6 months before trying to conceive may improve sperm quality and increase chances of conception. Many users reported successful pregnancies after pausing finasteride, with some switching to topical finasteride and oral minoxidil during this period.

community Have any of you given Nanoxidil a try?

4 upvotes 4 years ago

Nanoxidil is discussed as a potential alternative to Minoxidil for hair loss, with some users reporting better results and improved hair strength. However, concerns about its lack of FDA approval and potential scalp dryness are noted.

community 11 weeks post op !!!! What you think ?

in Is this regrowth? 66 upvotes 2 years ago

A user shared their 11-week post-op hair transplant results, noting they use only vitamins, not minoxidil or finasteride. Replies suggest starting finasteride to maintain results, with mixed opinions on the current progress.

community PP405: Regrows Hair In 8 Weeks. Is This The Miracle Cure?

168 upvotes 7 months ago

PP405 is considered as a potential hair regrowth treatment, but users are skeptical due to past product failures. They compare it to Minoxidil and Finasteride, questioning its effectiveness and the intentions of pharmaceutical companies.

community 42 male - 8 months (Is this the biological limit?)

58 upvotes 5 months ago

A 42-year-old male has reached a plateau in hair regrowth after 8 months using Dutasteride, Minoxidil, a dermaroller, and Ketoconazole. Suggestions include continuing treatment, considering a hair transplant, and improving nutrition.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Stem Cell Factor

learn omega-6

learn Omega 3

Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.

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