Gingerol Ameliorates Chronic Graft-Versus-Host Disease by Regulating Treg/Th17 Transdifferentiation

The study investigates the effects of gingerol on chronic graft-versus-host disease (cGVHD) using two mouse models. Gingerol was found to significantly improve survival rates, reduce body weight loss, and lower clinical cGVHD scores. It decreased tissue damage in the liver, lung, and GI tract and reduced serum inflammatory cytokines. Gingerol treatment led to a decrease in pro-inflammatory T cells and an increase in regulatory T cells. The study identified gingerol as a P2RY13 antagonist that modulates T cell activation and differentiation, offering a potential new treatment avenue for steroid-refractory cGVHD.