12 citations
,
June 2023 in “Journal of trace elements in medicine and biology” This study identified dose levels of selenium that can produce toxicity, noting that doses as low as 2-3 µg Se/kg bw/day can lead to adverse effects, and a human mortality study linked 300 µg/day consumption to increased death risk.
11 citations
,
April 2009 in “Pharmacotherapy” Minoxidil can cause deadly skin reaction; monitor patients closely.
9 citations
,
March 1968 in “The BMJ” In their 1957 study, Neuman and Neuman suggested that magnesium deficiency may inhibit the ion exchange process required for calcium ions to enter extracellular fluid, potentially affecting calcium mobilization.
7 citations
,
October 2019 in “Annals of palliative medicine” This review examines the incidence and management of dermatologic adverse effects from FDA-approved oral targeted cancer therapies, highlighting frequent occurrences like rashes and rarer severe conditions such as Stevens-Johnson Syndrome.
6 citations
,
December 2022 in “Toxicological Research”
6 citations
,
January 2019 in “Dermatology Research and Practice” This study found that ocular and mucocutaneous sequelae are common in SJS/TEN survivors, with exposure to sulfadoxine and severe acute ocular involvement identified as significant risk factors for ocular sequelae.
5 citations
,
August 2021 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association” This study observed that accidental topical minoxidil exposure can cause toxicosis in dogs and cats, leading to moderate or major illness, and even death in some cats.
5 citations
,
January 2016 in “BLDE University Journal of Health Sciences” This study observed that Kasisa Bhasma is safer and less toxic than Shodhita Kasisa, particularly at higher doses, when administered to experimental rats.
4 citations
,
November 2024 in “Toxicology Research” In this study, researchers reported that a combined formulation of curcumin and piperine in niosomal nanoparticles shows promise as a treatment for paraquat-induced lung toxicity, potentially due to improved bioavailability and strong antioxidant properties.
This book chapter discusses the mechanisms and prevention of selenium toxicity in livestock and reports no new experimental results; it emphasizes reducing selenium in the human food chain through animal products.
2 citations
,
May 1985 in “Environmental Health Perspectives” This report examines the mechanisms by which TCDD affects human epidermal and carcinoma cells, aiming to create a risk assessment model for halogenated aromatic compounds, but presents no new clinical results.
1 citations
,
May 2008 in “Toxicon” This study found that BOTOX doses of 75–100 U effectively reduce postvoiding residual urine and detrusor pressure in patients with detrusor sphincter dyssynergia.
1 citations
,
October 2024 in “Veterinary Sciences” In this case study, hemodialysis was reported as an effective treatment for a cat suffering from minoxidil toxicosis, leading to the cat's full recovery over an 11-day hospitalization period.
1 citations
,
December 2022 in “Pediatric dermatology” This case report highlighted an instance of lichen spinulosus emerging as a new cutaneous sequela in a boy following toxic epidermal necrolysis, responding to treatment with ammonium lactate.
1 citations
,
June 2022 in “JAAD case reports” This case report describes a woman who developed toxic epidermal necrolysis, potentially linked to an etonogestrel contraceptive implant, suggesting the need for further research into such adverse reactions.
1 citations
,
October 2021 in “Al-Rafidain journal of medical sciences.” This review discusses the toxic effects and mechanisms of platinum compounds in cancer treatment, emphasizing the need for new compounds with different mechanisms of action; it reports no new clinical results.
June 2025 in “Journal of Cluster Science” This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
March 2024 in “Tropical Journal of Natural Product Research” This study surveyed the use and potential toxicity of medicinal plants in the Fez-Meknes region of Morocco, documenting 59 toxic species used primarily for cosmetic purposes and minor illnesses, and identified hair loss and rheumatism as having the highest informant agreement ratios.
June 2026 in “Frontiers in Medicine” This study conducted a large-scale comparison using FAERS data to assess the post-marketing safety profiles of spironolactone, eplerenone, and finerenone, finding unique adverse event patterns for each drug and highlighting the need for personalized safety monitoring and further investigation in other pharmacovigilance databases.
January 2026 in “International Journal of Dermatology” This study analyzed social media posts to assess pet toxicosis from topical minoxidil exposure, finding that many pet owners were unaware of its toxicity risks, particularly for cats, and highlighted a significant need for increased educational efforts to prevent such incidents.
November 2025 in “Toxicology Communications” The study observed that topical minoxidil poses an increasing and potentially deadly risk to pets, particularly cats, highlighting the urgent need for better public education and product labeling.
September 2025 in “Toxins” Botulinum toxins show promise in treating various conditions, but more research is needed for hair and scalp disorders.
August 2025 in “Quality in Sport” In this review, the authors highlighted the importance of vitamin A for vision, immune function, growth, and skin, noting that deficiency can lead to serious health issues like night blindness and increased infection risk, while excessive intake poses toxicity risks, particularly from supplements.
This review discusses the use of botulinum toxin for hair and scalp disorders and reports mixed findings, with most studies showing mild or non-significant effects on hair growth.
January 2025 in “International journal of Indian medicine” This article discussed the potential risks of commercial hair oils, which may contain harmful ingredients, and suggested that additive-free ayurvedic oils could offer a safer alternative for maintaining healthy hair, while urging dermatologists to be informed about different herbal hair oil options.
December 2024 in “Jurnal Mandala Pharmacon Indonesia” In this study, high-dose oral administration of Ramania leaf ethanol extract in Wistar rats resulted in no significant acute toxicity symptoms, though gastric ulcers and hair loss were observed. The extract is classified as non-toxic under specified guidelines, with an LD50 greater than 5000 mg/kg.
September 2024 in “Meditsinskiy sovet = Medical Council” This article reports a rare case of toxic keratitis in a patient due to excessive intake of vitamin A, highlighting hypervitaminosis A risks such as severe eye conditions and systemic health issues, especially with cumulative doses exceeding therapeutic levels.
August 2024 in “Bioimpacts” In this study on mice, a hydro-alcoholic solution containing kopexil significantly enhanced hair growth and increased hair-promoting factors without causing notable liver or kidney toxicity compared to minoxidil.
In this systematic review, researchers observed that Toxoplasma gondii infection is associated with alterations in testosterone levels, generally increasing in humans but showing mixed effects in animals, highlighting a complex relationship that warrants further investigation.
March 2024 in “Journal of Pharmaceutical and Sciences” This study investigated the phytochemical composition and antibacterial and antioxidant activities of Zaleya pentandra extracts, finding high total polyphenol and flavonoid content and significant antibacterial effects, particularly in acetone extract, which may be suitable for developing antibacterial agents.