Toxic Effect of Platinum Compounds: Molecular Mechanisms of Toxicity

This review article discusses the toxic effects of platinum compounds used in chemotherapy, highlighting their serious side effects such as neurotoxicity, nephrotoxicity, ototoxicity, gastrointestinal toxicities, myelosuppression, and hair loss. These side effects occur because platinum compounds bind to both malignant and normal cells, particularly in fast-growing tissues. The article emphasizes the need for developing new platinum-based drugs with different mechanisms of action to mitigate these toxicities. The review includes studies published between 2005 and 2020 and suggests future research directions for safer chemotherapy options.