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GlossaryNephrotoxicity

harmful effects of substances on kidney function

Nephrotoxicity refers to the harmful effects that certain substances, such as drugs or toxins, can have on the kidneys. It can lead to kidney damage or impaired kidney function, which may manifest as reduced ability to filter waste from the blood, electrolyte imbalances, or even kidney failure. This condition is a significant concern in medical treatments involving potent medications like chemotherapy agents or certain antibiotics.

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research Zizyphus Jujuba Protects Against Ibuprofen-Induced Nephrotoxicity in Rats

15 citations, September 2013 in “Pharmaceutical Biology”

Jujube fruit extract may reduce kidney damage from ibuprofen in rats.

research Use of Mannitol Diuresis to Reduce Cisplatin Nephrotoxicity

August 1978 in “Dicp-The annals of pharmacotherapy”

Mannitol diuresis allows higher doses of cis-platinum for testicular cancer treatment without increasing kidney damage.

research Tacrolimus in Dermatologic Disorders

33 citations, May 2001 in “Annals of pharmacotherapy/The annals of pharmacotherapy”

Topical tacrolimus is safe and effective for skin conditions, but oral tacrolimus has serious side effects.

research Cyclosporine Therapy for Bullous Erythema Multiforme

18 citations, March 1990 in “Archives of Dermatology”

Cyclosporine cleared a woman's resistant skin condition quickly and kept it away for over a year.

research Toxic Effect of Platinum Compounds: Molecular Mechanisms of Toxicity

1 citations, October 2021 in “Al-Rafidain journal of medical sciences.”

Platinum compounds used in cancer treatment can cause serious side effects like organ damage and hair loss.

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community Will my liver get destroyed long term on this stack ??

in Chat 15 upvotes 10 months ago

A user is considering a long-term hair loss treatment stack including Dutasteride, Finasteride, and oral Minoxidil, and is concerned about potential liver damage. Some responses suggest the stack is excessive, while others believe it's not harmful to the liver, but recommend regular blood work to monitor health.

community This is what Six years of DUT looks like

in Finasteride/Dutasteride 791 upvotes 1 year ago

User had success with dutasteride for hair loss after finasteride didn't work. Some experienced increased cholesterol and debated its relation to DHT.

community My hair after 3 steroid cycles

in Progress Pictures 27 upvotes 5 months ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 2 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.