Introduction to Toxins Special Issue on Botulinum Toxins: New Uses in the Treatment of Diseases (2nd Edition)

This Special Issue examines new therapeutic applications of botulinum neurotoxins (BoNTs), particularly serotypes A and B, in treating various conditions. It includes 13 articles, with 10 focusing on humans and 3 on animals. Notable findings include BoNT/E's potential for managing chronic pain in rats, BoNT/A's role in nerve regeneration after injury, and its effectiveness in treating post-stroke spasticity. Additionally, BoNT/A shows promise in addressing movement disorders and conditions like Raynaud’s syndrome and psoriasis. However, BoNTs demonstrate limited efficacy for hair and scalp disorders, highlighting the need for larger, controlled studies to reach definitive conclusions. Overall, the issue enhances understanding of BoNTs' novel applications in improving human health.