Pharmacovigilance Profiles of Three Generations of Mineralocorticoid Receptor Antagonists and Network Toxicology Analysis

    June 2026 in “ Frontiers in Medicine ”
    Hai-Hong Lin, Wen-Hui Cui, Feng Xu … Kaili Mao
    Studysummary This study conducted a large-scale comparison using FAERS data to assess the post-marketing safety profiles of spironolactone, eplerenone, and finerenone, finding unique adverse event patterns for each drug and highlighting the need for personalized safety monitoring and further investigation in other pharmacovigilance databases.
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    Research cited in this study 2

    1. Analyzing Real-World Adverse Events of Spironolactone with the FAERS Database PLoS ONE · 2025
    2. Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss PubMed · 2010