Analyzing Real-World Adverse Events of Spironolactone with the FAERS Database

    September 2025 in “ PLoS ONE ”
    Guowei Lin, Ru Chen, Chaoning Wen … Lixian Li
    Studysummary In this study, researchers used the FAERS database to identify rare adverse events potentially linked to spironolactone, finding new safety signals such as a possible association with male endometriosis, suggesting further research is needed to understand these findings better.
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    Research cited in this study 2

    1. Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review American Journal of Clinical Dermatology · 2017
    2. Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss PubMed · 2010