Risks Associated With 5α-Reductase Inhibitor Use: Analysis of Adverse Drug Reactions Reported to EudraVigilance

    June 2026 in “ Pharmaceuticals ”
    Ricardo Alves, Samuel Silvestre, Cristina Monteiro
    Studysummary This study found that while 5α-reductase inhibitors like finasteride had many serious, unresolved adverse drug reactions, some were not listed in the existing product information.
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    Research cited in this study 15

    1. Failing Public Health Again? Analytical Review of Depression and Suicidality From Finasteride The Journal of Clinical Psychiatry · 2025
    2. Finasteride and Dutasteride for the Treatment of Male Androgenetic Alopecia: A Review of Efficacy and Reproductive Adverse Effects Georgetown medical review · 2023
    3. 5-Alpha Reductase Inhibitors Use in Prostatic Disease and Beyond Translational Andrology and Urology · 2023
    4. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    5. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    6. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm The World Journal of Men's Health · 2020
    7. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    8. A Population-Based Study of the Risk of Osteoporosis and Fracture with Dutasteride and Finasteride BMC Musculoskeletal Disorders · 2018
    9. Effects of 5-Alpha Reductase Inhibitors Current Opinion in Urology · 2018
    10. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
    11. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    12. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016
    13. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    14. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    15. Combination Therapy With Finasteride and Low-Dose Dutasteride in the Treatment of Androgenetic Alopecia Australasian Journal of Dermatology · 2012