A Population-Based Study of the Risk of Osteoporosis and Fracture with Dutasteride and Finasteride

May 2018 in “ BMC Musculoskeletal Disorders ”

Tony Antoniou, Erin MacDonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne Man-Wai Ho, Muhammad Mamdani, David N. Juurlink

dutasteride finasteride Avodart Propecia

TLDR Dutasteride and finasteride have similar risk for osteoporosis and fractures in older men.

A population-based study from 2018 compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride. The study found that there was no significant difference in the risk of osteoporosis or fractures between the two medications. The study concluded that dutasteride can be used safely in terms of adverse bone outcomes among older men.

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research A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

22 citations , November 2014 in “Clinical endocrinology”

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

research The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men

72 citations , June 2008 in “The Journal of urology/The journal of urology”

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , May 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research Dihydrotestosterone and the Concept of 5-Alpha-Reductase Inhibition in Human Benign Prostatic Hyperplasia

184 citations , January 2000 in “European Urology”

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.