A Population-Based Study of the Risk of Osteoporosis and Fracture with Dutasteride and Finasteride

May 2018 in “ BMC Musculoskeletal Disorders ”

Tony Antoniou, Erin MacDonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne Man-Wai Ho, Muhammad Mamdani, David N. Juurlink

dutasteride finasteride Avodart Propecia

TLDR Dutasteride and finasteride have similar risk for osteoporosis and fractures in older men.

A population-based study from 2018 compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride. The study found that there was no significant difference in the risk of osteoporosis or fractures between the two medications. The study concluded that dutasteride can be used safely in terms of adverse bone outcomes among older men.

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Research cited in this study

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A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

research A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

22 citations, August 2014 in “Clinical endocrinology”

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men

research The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men

72 citations, April 2008 in “The Journal of urology/The journal of urology”

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations, February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research Dihydrotestosterone and the Concept of 5-Alpha-Reductase Inhibition in Human Benign Prostatic Hyperplasia

184 citations, January 2000 in “European Urology”

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.

Related Community Posts Join

6 / 1000+ results

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 90 upvotes 3 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community How do people afford finasteride/dutasteride?

in Treatment 27 upvotes 5 months ago

People discuss the high cost of brand name finasteride and dutasteride, suggesting generics as cheaper alternatives. They share prices from various regions, highlighting significant cost differences.

community Should I be hopeful? Oral min 5mg dutasteride 1mg

in Is this regrowth? 22 upvotes 7 months ago

The conversation discusses hair loss treatments including oral minoxidil 5mg, dutasteride 1mg, and suggestions to use a derma stamp on the scalp. Some users believe these treatments can improve hair condition or at least stabilize loss, while one suggests considering a hair transplant after a year if desired.

community Switched from fin to dut. See you guys in three months

in Progress Pictures 10 upvotes 5 months ago

A user switched from finasteride to Avodart (dutasteride) due to the ineffectiveness and poor quality of finasteride in their country. They advise others in similar situations to seek original brands.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 372 upvotes 3 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community DHT LEVEL IS 700pg/ml AFTER 8 MONTHS OF DUTASTERIDE

in Finasteride/Dutasteride 22 upvotes 1 month ago

The user had high DHT levels after 8 months on dutasteride, questioning the drug's authenticity. They got dutasteride from a legitimate source and will update on progress.

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research The Shifting Preferences of Patients and Physicians in Nonsurgical Hair Loss Treatment

7 citations, September 2020 in “Journal of Cosmetic Dermatology”

Minoxidil and Finasteride are the most popular hair loss treatments, with rising interest in other options, and economic or health crises can change what treatments people prefer.

research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

November 2020 in “Elsevier eBooks”

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

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research Dutasteride/Finasteride: A Retrospective Study on Macular Abnormalities in Male Patients Treated for Benign Prostatic Hypertrophy or Alopecia

February 2021 in “Reactions Weekly”

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A 25-Year-Old Man with Androgenetic Alopecia Developed Symptoms of Post-Finasteride Syndrome After Treatment with Finasteride and Dutasteride

research A 25-Year-Old Man with Androgenetic Alopecia Developed Symptoms of Post-Finasteride Syndrome After Treatment with Finasteride and Dutasteride

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Man experienced post-finasteride syndrome symptoms after using finasteride and dutasteride for hair loss.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.