Toxic Epidermal Necrolysis Caused by Etonogestrel Implantation: A Rare Presentation

The document presents a case of a 34-year-old woman who developed toxic epidermal necrolysis (TEN) 14 days after the implantation of an etonogestrel contraceptive implant (Nexplanon). This is the first documented case of skin sloughing, skin necrosis, or epidermolysis related to etonogestrel implantation. The patient's condition improved after the implant was removed. The cause of TEN in this case remains unclear, but the authors suggest it could be due to therapeutic or supratherapeutic levels of etonogestrel or another compound used in the implant, namely, barium sulfate. The authors conclude that future studies on the potential of the etonogestrel implant to cause TEN should be strongly considered to mitigate the possibility of future events.