Long-Term Complications of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: The Spectrum of Chronic Problems in Survivors Necessitates Multidisciplinary Follow-Up

The document reviewed the range of long-term complications in survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), highlighting the need for comprehensive, multidisciplinary follow-up care. Dermatological issues, such as post-inflammatory dyspigmentation and scarring, were common and significantly affected quality of life. Ocular complications were particularly disabling, affecting 20-75% of survivors and often leading to severe visual impairment. Other noted sequelae included chronic oral and dental issues, pulmonary problems with over 50% of 32 survivors showing abnormal pulmonary function tests, urogenital lesions in 28% of patients, gastrointestinal and hepatic complications, and acute kidney injury in about 20% of cases. Psychiatric issues like depression and PTSD were also prevalent, with many survivors facing long-term psycho-social challenges. The document stressed the importance of early intervention, long-term management, and the need for a large-scale prospective study to better understand the full scope of chronic SJS/TEN complications.