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      learn Neem Oil

      natural substance from Neem tree with medicinal and pesticidal properties

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn Dutasteride

      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

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      a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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      Can liver problems be associated with response to the oral minoxidil?

      community Can liver problems be associated with response to the oral minoxidil?

      in Research  147 upvotes 3 weeks ago
      Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

      community Scalp Doesnt Absorbe Minoksidil

      in Minoxidil  1 upvotes 2 days ago
      The user experienced hair regrowth using a combination of finasteride and minoxidil, but had to stop due to liver issues and switched to dutasteride. After resuming dutasteride and minoxidil, they faced absorption issues with minoxidil and sought advice on improving absorption.

      community From finasteride to Serenoa repens

      in Treatment  1 upvotes 2 months ago
      The user experienced anxiety and side effects from topical finasteride and is considering switching to saw palmetto. Another user reported no improvement with saw palmetto and experienced liver issues.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.