Cutaneous and Ocular Sequelae of Stevens-Johnson Syndrome and Lyell Syndrome
December 2010
in “
Annales de Dermatologie et de Vénéréologie
”
Stevens-Johnson syndrome Lyell syndrome hyperchromic macules photosensitivity hair loss abnormal sweating nail loss vaginal adhesions photophobia chronic lacrimation eyelid malpositions symblepharon superficial punctate keratitis dry eye syndrome SJS toxic epidermal necrolysis dark spots sensitivity to light alopecia excessive sweating onycholysis vaginal scarring light sensitivity tearing eyelid misalignment eyelid adhesion corneal inflammation dry eyes
TLDR The conclusion is that skin, mucous, and eye problems after Stevens-Johnson syndrome and Lyell syndrome significantly affect patients' lives, highlighting the need for comprehensive care and eye check-ups.
The study conducted at Ibn Rochd University Hospital in Casablanca analyzed 43 cases of Stevens-Johnson syndrome (SJS) and Lyell syndrome from 1986 to 2006, with patients averaging 28 years old and followed for three years. It found that mucocutaneous sequelae included hyperchromic macules with scarring (72%), photosensitivity (70%), hair loss (23%), abnormal sweating (19%), nail loss (19%), and vaginal adhesions (5%). Ocular sequelae were significant, with 70% experiencing photophobia and chronic lacrimation, 21% with eyelid malpositions, 30% with symblepharon, 42% with superficial punctate keratitis, and 56% with dry eye syndrome. These sequelae greatly affected patients' social and professional lives, with 70% having difficulties reading or performing manual work. The study emphasized the need for multidisciplinary care and regular ophthalmological monitoring due to the lack of preventive treatments for ocular sequelae and the impact on quality of life.
