21 citations,
August 1987 in “Archives of Dermatology” High-dose methotrexate can cause severe skin and nail issues.
10 citations,
January 2013 in “International Journal of Trichology” Systemic steroids effectively treated severe nail issues in a card illusionist with alopecia areata.
8 citations,
May 2021 in “Journal of the European Academy of Dermatology and Venereology” A COVID-19 patient had unusual nail discoloration and nail separation possibly due to the virus's effects on small blood vessels.
6 citations,
October 2006 in “International Journal of Dermatology” Hair splitting and nail detachment are linked conditions.
February 2010 in “Journal of The American Academy of Dermatology” A woman's nail separation was likely caused by poor blood flow, and a treatment for similar conditions might help.