Synergistic Effect of Curcumin and Piperine Loaded Niosomal Nanoparticles on Acute Pulmonary Toxicity Induced by Paraquat in Mice

    November 2024 in “ Toxicology Research ”
    Aram Khederzadeh, Pedram Ebrahimnejad, Mohammad Seyedabadi, Amirhossein Babaei, Fereshteh Talebpour Amiri, Nasim Aslani, Solmaz Mojarad-Jabali, Hamidreza Mohammadi
    Studysummary In this study, researchers reported that a combined formulation of curcumin and piperine in niosomal nanoparticles shows promise as a treatment for paraquat-induced lung toxicity, potentially due to improved bioavailability and strong antioxidant properties.
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    The study investigates the therapeutic potential of a combined formulation of curcumin and piperine loaded in niosomal nanoparticles to treat acute pulmonary toxicity induced by paraquat (PQ) in mice. The results suggest that this combination offers a promising strategy due to its enhanced bioavailability and potent antioxidant activity, which may effectively mitigate the toxic effects of PQ on the lungs.
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