Tea Polyphenol–Zinc Nanocomplexes Alleviate Diquat-Induced Liver and Small Intestine Oxidative Stress in C57BL/6 Mice

The study examined the effects of tea polyphenol–zinc nanocomplexes (Tp-Zn) on diquat-induced oxidative stress in C57BL/6 mice, involving 5 groups of 6 mice each. Tp-Zn significantly reduced oxidative stress in the liver and small intestine by enhancing antioxidant enzyme activities and reducing oxidative damage markers. It improved liver function by lowering serum levels of AST, ALT, and AKP, and enhanced intestinal barrier integrity by upregulating tight junction proteins. The protective effects are likely mediated through the activation of the Nrf2 signaling pathway, suggesting Tp-Zn as a promising therapeutic agent for oxidative stress-related conditions.