Encapsulation of Curcumin into Nanoparticles

    January 2010
    Natthakitta Suwannateep
    TLDR Encapsulating curcumin in nanoparticles improves its stability, release, and absorption in the body.
    The study investigated the encapsulation of curcumin into nanoparticles using five different polymers, achieving over 90% encapsulation efficiency. The encapsulated curcumin demonstrated significantly improved photostability compared to free curcumin. In vitro and in vivo studies showed that curcumin-loaded nanoparticles, particularly those using ethyl cellulose (EC) and methylcellulose (ECMC), had enhanced release profiles and bioavailability in mice, adhering to stomach mucosa and maintaining higher blood concentrations. Additionally, skin penetration studies indicated that curcumin was effectively delivered through hair follicles, with water-in-oil lotions enhancing penetration more than oil-in-water lotions.
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