TLDR A woman's severe skin reaction was caused by an allergy to a skin treatment.
In 1968, a 47-year-old woman with a history of rubber dermatitis developed toxic epidermal necrolysis after using a monosulfiram solution, an antiscabetic agent. She presented with fever, rash, and skin shedding but had normal blood and urine tests, and no bacteria in her pustules. Her condition improved with triamcinolone and fluocinolone treatment, although she experienced temporary hair loss and nail changes, recovering after three months. Patch testing indicated a hypersensitivity to tetramethylthiuram disulphide, related to monosulfiram. This case underscores the risk of severe skin reactions from topical treatments and the need to consider a patient's hypersensitivity history.
74 citations,
September 1980 in “Medical Clinics of North America” Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.
48 citations,
November 1992 in “International Journal of Dermatology” Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.
25 citations,
July 1991 in “International Journal of Dermatology” Toxic Epidermal Necrolysis is a rare, serious skin condition that can affect anyone, is more common in women, and may be linked to genetics, with a 20% mortality rate mainly due to sepsis.
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105 citations,
February 2017 in “British Journal of Dermatology” Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.
35 citations,
May 2008 in “Journal of Clinical Oncology” A cancer patient died from a severe skin reaction after taking the drug cetuximab.
