Suéllen Pedrosa da Silva, Clarice Barbosa Lucena da Costa, Anderson Felipe Soares de Freitas, José Dayvid Ferreira da Silva, Wêndeo Kennedy Costa, Wênio Sandoval Filho Lima da Silva, Janaína Carla Barbosa Machado, Sandra Maria Souza da Silva, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares, Jacinto da Costa Silva Neto, Márcia Vanusa da Silva, Alisson Macário de Oliveira, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão
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Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.
Peppermint Essential Oil (PEO) was discussed for its hair regrowth effects on shaved mice after 4 weeks. Specific treatments mentioned include Minoxidil (Min), Finasteride (Fin), and RU58841 (RU).
Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.
Mixing retinol, rosemary oil, and minoxidil on the scalp may cause burning but no significant damage is mentioned. Another user plans to use peppermint oil instead of minoxidil due to its side effects.
The user experiences irritation from alcohols in minoxidil and is considering alternatives like trichosol mixed with polyethylene glycol or DMSO. They seek advice on the best nonirritating option.