In Vitro and In Vivo Evaluation of the Photochemopreventive Potential of Lychnophora Salicifolia Mart. Extract and Chlorogenic Acid Free and Incorporated in Liposomes

The study evaluated the photochemopreventive potential of Lychnophora salicifolia Mart. extract and chlorogenic acid, both free and incorporated in liposomes, through in vitro and in vivo tests. The extract demonstrated antioxidant activity, low cytotoxicity, and enhanced skin penetration when formulated with liposomes. It effectively scavenged intracellular ROS, prevented GSH depletion, and inhibited MMP-9, which is activated by UVR and degrades skin matrix components. Additionally, the extract exhibited significant anti-inflammatory properties by reducing cytokine levels and myeloperoxidase activity. These findings suggested that the extract could be a viable topical photochemopreventive agent, with liposome formulations enhancing its delivery to the skin.