In Vitro Evaluation of the Cytotoxic Potential of Alpinia Speciosa, Ageratum Conyzoides, and Dysphania Ambrosioides Oils on Prostate Cancer, Histiocytic Lymphoma, and Chronic Myeloid Leukemia Cell Lines

    January 2017 in “ Anais do 5º Encontro Brasileiro para Inovação Terapêutica ”
    Vitor Alfredo de Santana Silva, M. A. B. CORREIA, Moacyr Jesus Barreto de Melo Rêgo, Marina Couto Pereira, Rita de Cássia da Silveira e Sá, Reginaldo Ferreira Santos, T. G. J. SILVA, Karina Perrelli Randau, I. R. PITTA, Maíra Galdino da Rocha Pitta
    TLDR The oils showed potential to kill certain cancer cells, especially from Dysphania ambrosioides.
    The study evaluated the cytotoxic effects of oils from the leaves of Alpinia speciosa, Ageratum conyzoides, and Dysphania ambrosioides on prostate cancer, histiocytic lymphoma, and chronic myeloid leukemia cell lines. Using the MTT assay on DU-145, U-937, and K-562 cell lines, it was found that all three oils exhibited cytotoxicity on the K-562 cell line at specific doses, with IC50 values of 1.7x10-3%, 5x10-3%, and 3x10-2%, respectively. In the U-937 cell line, only D. ambrosioides oil showed cytotoxicity at a dose of 2.5x10-2% (IC50 2.4x10-2%). The study concluded that further research was needed to understand the mechanisms of action, particularly for D. ambrosioides in histiocytic lymphoma and chronic myeloid leukemia cell lines.
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