May 2026 in “The EMBO Journal” This study explores the complex mechanisms of skin aging, including cellular senescence and disrupted communication, and highlights rejuvenation strategies like gene expression rewiring and microbiome modulation, offering potential frameworks for regenerative therapies and precise interventions in skin and systemic aging.
February 2026 in “BMC Plastic and Reconstructive Surgery” This review suggests that induced pluripotent stem cells (iPSCs) hold promise for treating chronic wounds, but further work is needed to address safety, efficacy, and translation from preclinical models to real-world applications.
August 2023 in “Journal of controlled release” This research found that STAR particles, ceramic particles with microneedles, significantly enhance skin permeability and improve the topical delivery of drugs like minoxidil and acyclovir, effectively promoting or inhibiting hair growth without causing skin irritation in ex vivo pig skin and rat models.
This review reports that thermal spring waters, enriched with a diverse hydrobiome, hold promising potential for use in dermocosmetics, as their bioactive compounds could enhance skin protection, repair, and appearance, benefiting conditions like atopic dermatitis and rosacea.
June 2008 in “Experimental dermatology” This research found that melatonin plays a protective and modulatory role in skin biology, reducing UV damage and chemotherapy-induced hair follicle cell harm in human organ culture models.
19 citations
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August 2007 in “Seminars in Plastic Surgery” This review discusses five popular resurfacing technologies for facial rejuvenation, highlighting their role in achieving smoother, healthier, and younger-looking skin, and reports no new clinical results.
March 2026 in “DergiPark (Istanbul University)” In this study, BTP-loaded solid lipid nanoparticles were developed and shown to protect hair from heat-induced damage by enhancing cuticle integrity and thermal resistance in simulated thermal straightening conditions.
28 citations
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March 2017 in “Scientific Reports” This study found that minoxidil may protect against chemotherapy-induced peripheral neuropathy and potentially support hair recovery and tumor suppression in mouse models.
156 citations
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August 2016 in “Journal of controlled release” This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.
48 citations
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September 2017 in “Frontiers in Bioscience” This review explores the role of nanotechnology in wound healing, highlighting its potential through antimicrobial properties, selective inflammatory action, angiogenesis promotion, and its use in drug and gene delivery.
29 citations
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March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
24 citations
,
August 2021 in “Scientific Reports” This study found that non-thermal atmospheric pressure plasma may stimulate hair growth through activation of the Wnt/β-catenin signaling pathway, suggesting it could be a potential non-pharmacological treatment for alopecia.
7 citations
,
December 2021 in “Pharmaceutics” This review examines the anti-alopecia effects of plant-derived phytochemicals and their mechanisms for promoting hair growth, but it reports no new clinical findings.
19 citations
,
July 2019 in “Journal of Endocrinology” This study found that GTx-024 and Danazol had similar effects to dihydrotestosterone on uterine tissue in mice, while GTx-007 showed minimal impact on the parameters tested.
12 citations
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April 2019 in “Scientific Reports” This study found that HMGB1 enhanced hair growth by stimulating PGE2 production in human dermal papilla cells, suggesting a potential therapeutic target for alopecia treatment.
October 2025 in “Journal of Nanobiotechnology” This study reports that using a hydrogel-based therapy that dynamically regulates reactive oxygen species helps achieve skin regeneration in infected wounds, promoting organized dermal architecture with improved hair follicle and blood vessel formation, rather than scar formation.
7 citations
,
September 2024 in “PLANT PHYSIOLOGY” This study in Arabidopsis thaliana found that exposure to volatile compounds from Penicillium aurantiogriseum promotes root hair growth through signaling involving RALF22, ethylene, auxin, and photosynthesis, and that RALF22 plays a crucial role in the plants' response to these compounds.
79 citations
,
January 2019 in “International Journal of Molecular Sciences” This study characterized the inflammatory response in a murine burn model, revealing similarities to human burns and supporting the model's use in testing therapies for burn complications.
18 citations
,
May 2022 in “Stem Cell Research & Therapy” This study found that irradiating human adipose-derived stem cells with green OLEDs enhanced their wound healing capability and increased cell proliferation, migration, and adhesion in preclinical models.
This study observed that a combination of sinapic acid and glabridin from Zhimo herbal extract improved hair growth and reduced oxidative stress in a DHT-induced model of androgenetic alopecia in mice by preventing ferroptosis and stabilizing β-Catenin, offering potential application for AGA treatment.
53 citations
,
July 2016 in “Cosmetics” This study reviews the biology and cosmetic treatment of hair, emphasizing future advancements in safer, more effective procedures to meet consumer needs for hair care.
1 citations
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July 2025 in “Journal of Photochemistry and Photobiology B Biology” Photobiomodulation helps protect hair follicle cells from damage caused by DHT.
May 2026 in “Medical Sciences” This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.
10 citations
,
May 2024 in “BioEssays” This review examined the role of the ion channel TRPV3 in warmth sensation and skin physiology, discussing controversies around its direct contribution to temperature perception, its involvement in skin health, and its potential as a therapeutic target for skin diseases.
May 2026 in “Journal of Health Sciences and Medicine” This study found that biotinoyl tripeptide-1-loaded solid lipid nanoparticles significantly improved thermal protection in hair, enhancing cuticle integrity and resistance to heat damage, compared to control samples.
March 2026 in “ACS Applied Bio Materials” In this study, a copolymer made from Tung oil and Tung free fatty acids demonstrated improved mechanical and thermal properties for hair repair, with enhanced resistance and flexibility observed in treated bleached hair, suggesting its potential as a sustainable biopolymer for cosmetic applications.
143 citations
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January 2004 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.
88 citations
,
August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
19 citations
,
December 2021 in “Stem Cell Research & Therapy” This study found that Muse cells, when injected subcutaneously, alleviated symptoms of atopic dermatitis in mice, suggesting potential for treating inflammatory skin conditions.
7 citations
,
January 2025 in “Current Issues in Molecular Biology” This study found that PDRN derived from Lactobacillus rhamnosus showed superior antioxidant and wound-healing properties compared to salmon-derived PDRN, while also offering potential benefits in immune modulation and bioavailability.