Multilineage-Differentiating Stress-Enduring Cells Alleviate Atopic Dermatitis-Associated Behaviors in Mice

    December 2021 in “ Stem Cell Research & Therapy ”
    WenDi Fei, Junlin Wu, Meng-Die Gao, Qian Wang, Ya Yu Zhao, Chunli Shan, Yu Shen, Gang Chen
    Studysummary This study found that Muse cells, when injected subcutaneously, alleviated symptoms of atopic dermatitis in mice, suggesting potential for treating inflammatory skin conditions. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that multilineage-differentiating stress-enduring (Muse) cells, derived from human bone marrow mesenchymal stem cells, significantly alleviated atopic dermatitis (AD)-associated behaviors in a mouse model. Muse cells reduced scratching behavior, decreased dermatitis severity, and promoted healing of damaged skin. They suppressed inflammatory factors such as IL-6, IL-17α, and IL-33 in the spinal cord and skin, and exhibited anti-inflammatory effects and enhanced wound healing in vitro. The study involved 3-6 mice per group and suggested that Muse cells could potentially serve as a new therapeutic agent for treating AD by modulating immune responses and reducing inflammation.
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