Mesenchymal Stem/Stromal Cell Therapy in Atopic Dermatitis and Chronic Urticaria: Immunological and Clinical Viewpoints

October 2021 in “ Stem Cell Research & Therapy ”

Eun‐Young Kim, Hyuk Soon Kim, Ki‐Sung Hong, Hyung‐Min Chung, Se‐Pill Park, Geunwoong Noh

mesenchymal stem cells mesenchymal stromal cells atopic dermatitis chronic urticaria immune modulation allergen-specific IgE mast cell degranulation autoimmune mechanisms MSCs AD CU

TLDR Mesenchymal stem cells may effectively treat and prevent allergic skin conditions.

The review discussed the potential of mesenchymal stem/stromal cell therapy (MSCT) for treating atopic dermatitis (AD) and chronic urticaria (CU) by modulating immune responses and offering symptomatic relief. Mesenchymal stem cells (MSCs) were noted for their ability to restore immune balance, reduce allergen-specific IgE, and inhibit mast cell degranulation, suggesting effectiveness against autoimmune mechanisms. Animal studies and clinical trials, including a 2017 trial with 37 AD patients and a 2020 study with 10 CU patients, showed promising results with reduced symptoms and improved clinical scores. These findings highlighted MSCs' anti-allergic and immunomodulatory roles, suggesting their suitability for treating AD and CU, though further research was needed to fully understand their mechanisms.

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AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

research AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

17 citations , March 2021 in “Expert Opinion on Biological Therapy”

Use PRP and ASC-BT for hair loss and wound healing, but more research needed.

research Systematic Review: Allogenic Use of Stromal Vascular Fraction and Decellularized Extracellular Matrices as Advanced Therapy Medicinal Products in Tissue Regeneration

113 citations , July 2020 in “International Journal of Molecular Sciences”

Allogenic ASCs and ECM transplants are safe and effective for tissue regeneration.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations , June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

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