The Suitability of Mesenchymal Stem Cells for Treating Immune-Mediated Inflammatory Skin Diseases: A Systematic Review

July 2025 in “ Dermatology Reports ”

Elena Pezzolo, Sara Di Leo, Paola Miceli, Alvise Sernicola, Luigi Naldi

mesenchymal stem cells MSC therapy immune-mediated inflammatory skin diseases alopecia areata systemic sclerosis systemic lupus erythematosus

TLDR Mesenchymal stem cell therapy shows promise for treating certain inflammatory skin diseases, but more research is needed.

Mesenchymal stem cell (MSC) therapy shows promise for treating immune-mediated inflammatory skin diseases (IMIDs) like alopecia areata, systemic sclerosis, and systemic lupus erythematosus, with improvements or complete remission observed in up to 100% of cases. A review of 18 clinical trials and 5 observational studies involving 609 patients found that adverse events were generally mild, and deaths were rare. MSC therapy may benefit patients unresponsive to conventional treatments, but further large controlled trials are needed to confirm its efficacy and safety due to the current evidence's heterogeneity.

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The Suitability of Mesenchymal Stem Cells for Treating Immune-Mediated Inflammatory Skin Diseases: A Systematic Review

Research cited in this study

research Clinical Efficacy of Adipocyte-Derived Stem Cells Conditioned Media Combined with Micro-Injury in Refractory Patch of Alopecia Areata

research Wharton's Jelly-Derived Mesenchymal Stem Cells in the Treatment of Four Patients with Alopecia Areata

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

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