Enhancing Therapeutic Efficacy of Human Adipose-Derived Stem Cells by Modulating Photoreceptor Expression for Advanced Wound Healing

May 2022 in “ Stem Cell Research & Therapy ”

Sang Ho Lee, Yujin Kim, Yeong Hwan Kim, Han Young Kim, Suk Ho Bhang

human adipose-derived stem cells hADSCs photoreceptor OPN4 green OLED irradiation wound healing cell proliferation cell migration cell adhesion growth factor expression

TLDR Green OLED light improves stem cell effectiveness for better wound healing.

The study investigated the effects of green OLED irradiation on human adipose-derived stem cells (hADSCs) to enhance their therapeutic efficacy for wound healing. It was found that the photoreceptor OPN4 in hADSCs was stimulated by the irradiation, leading to increased cell proliferation, migration, adhesion, and growth factor expression. This resulted in improved wound healing in vivo compared to non-irradiated hADSCs. The study concluded that green OLED irradiation, with a wavelength peak of 532 nm, could enhance the wound healing capabilities of hADSCs, indicating potential preclinical applications for this technique.

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