Enhancing Therapeutic Efficacy of Human Adipose-Derived Stem Cells by Modulating Photoreceptor Expression for Advanced Wound Healing

May 2022 in “ Stem Cell Research & Therapy ”

Sang Ho Lee, Yujin Kim, Yeong Hwan Kim, Han Young Kim, Suk Ho Bhang

human adipose-derived stem cells hADSCs photoreceptor OPN4 green OLED irradiation wound healing cell proliferation cell migration cell adhesion growth factor expression

TLDR Green OLED light improves stem cell effectiveness for better wound healing.

The study investigated the effects of green OLED irradiation on human adipose-derived stem cells (hADSCs) to enhance their therapeutic efficacy for wound healing. It was found that green OLED light activated OPN4 in hADSCs, leading to increased cell proliferation, migration, adhesion, and growth factor expression. The conditioned medium from irradiated hADSCs promoted the proliferation of human dermal fibroblasts and keratinocytes. In vivo tests in mouse models showed that irradiated hADSCs improved wound healing more effectively than non-irradiated cells. The study concluded that green OLED irradiation could enhance the wound healing capabilities of hADSCs, indicating potential preclinical applications for regenerative medicine.

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