Selective Androgen Receptor Modulators Have Specific Impacts on the Mouse Uterus

The study investigated the effects of selective androgen receptor modulators (SARMs) on the mouse uterus, specifically comparing GTx-007 and GTx-024 with Danazol and dihydrotestosterone (DHT). It found that GTx-024, Danazol, and DHT significantly increased body and uterine weight, as well as endometrial surface area, while GTx-007 did not. GTx-024 uniquely increased epithelial cell proliferation, whereas GTx-007 increased uterine expression of Wnt4 and Wnt7a, unlike GTx-024 and Danazol, which decreased their expression. The study involved 8-14 mice per treatment group and concluded that GTx-024 and Danazol had effects similar to DHT, while GTx-007 had minimal impact, highlighting differences in SARMs' effects on uterine tissue. The findings suggested potential therapeutic opportunities for SARMs in treating muscle-wasting disorders in women, though further studies were necessary to evaluate their safety and efficacy.