Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

    October 2009 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Azriel Schmidt, Shun Ichi Harada, Donald B. Kimmel, Chang Bai, Fang Chen, Su Jane Rutledge, Robert L. Vogel, Angela Scafonas, Michael A. Gentile, Pascale V. Nantermet, Sheila McElwee-Witmer, Brenda L Pennypacker, P. Masarachia, Soumya P. Sahoo, Yun-Tae Kim, Robert Meißner, George D. Hartman, Mark E. Duggan, Gideon A. Rodan, Dwight A. Towler, William J. Ray
    TLDR Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.
    The study identified and characterized selective androgen receptor modulators (SARMs), specifically TFM-4AS-1 and FTBU-1, which promoted bone and muscle growth while minimizing effects on reproductive organs and sebaceous glands. TFM-4AS-1 acted as a partial agonist, increasing bone and muscle mass in ovariectomized rats without promoting prostate growth, and showed partial antagonism in prostate and seminal vesicle growth. FTBU-1, a non-steroidal SARM, exhibited similar gene selectivity with improved solubility and no 5α-reductase inhibition, demonstrating anabolic effects on bone with minimal impact on the uterus. These findings suggested that SARMs like TFM-4AS-1 and FTBU-1 could provide safer therapeutic options for conditions like muscle wasting and osteoporosis, avoiding the side effects of traditional androgen therapy.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 178 results

      community The most nuclear stack possible

      in Satire  37 upvotes 1 week ago
      A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

      community So we’re just ok with taking a research chemical now?

      in Treatment  179 upvotes 4 years ago
      The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 1 year ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

    Similar Research

    5 / 1000+ results