Selective Androgen Receptor Modulators: A Critical Appraisal

    September 2025 in “ Frontiers in Endocrinology ”
    Peter Bond, Diederik L. Smit, Tijs Verdegaal, Willem de Ronde
    Studysummary This review critically evaluates the evidence for SARMs' tissue selectivity and suggests their clinical benefits over traditional androgens are not yet well-supported by robust evidence, underscoring the need for further head-to-head trials.
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    Research cited in this study 7

    1. Therapeutic Strategies to Target the Androgen Receptor Journal of Medicinal Chemistry · 2022
    2. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012
    3. The Selective Androgen Receptor Modulator GTx-024 (Enobosarm) Improves Lean Body Mass and Physical Function in Healthy Elderly Men and Postmenopausal Women: Results of a Double-Blind, Placebo-Controlled Phase II Trial Journal of cachexia, sarcopenia and muscle · 2011
    4. Mechanism of Action of Bolandiol (19-Nortestosterone-3β,17β-Diol), a Unique Anabolic Steroid with Androgenic, Estrogenic, and Progestational Activities Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2009
    5. Pharmacology of Anabolic Steroids British Journal of Pharmacology · 2008
    6. Finasteride Drugs · 1999
    7. Finasteride The New England Journal of Medicine · 1994