Therapeutic Strategies to Target the Androgen Receptor

    July 2022 in “ Journal of Medicinal Chemistry ”
    Weiguo Xiang, Shaomeng Wang
    Studysummary This review discusses various compounds targeting the androgen receptor, including recent developments in heterobifunctional degraders for prostate cancer treatment, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on hdl.handle.net →
    Discuss this study in the Community →

    Research cited in this study 15

    1. A Phase IIA Randomized, Placebo-Controlled Clinical Trial to Study the Efficacy and Safety of the Selective Androgen Receptor Modulator (SARM), MK-0773 in Female Participants with Sarcopenia Journal of Nutrition Health & Aging · 2013
    2. Clinical Biochemistry of Dihydrotestosterone Annals of Clinical Biochemistry · 2013
    3. Pantolactams as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2011
    4. Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery Journal of Medicinal Chemistry · 2010
    5. Diphenyl Ethers as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2009
    6. 4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2009
    7. Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications Journal of medicinal chemistry · 2008
    8. Pharmacology of Anabolic Steroids British Journal of Pharmacology · 2008
    9. (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    10. Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    11. Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    12. Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators Journal of medicinal chemistry · 2004
    13. Current Aspects of Antiandrogen Therapy in Women Current Pharmaceutical Design · 1999
    14. Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994
    15. RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994