Current Aspects of Antiandrogen Therapy in Women

    January 1999 in “ Current Pharmaceutical Design
    Evanthia Diamanti-Kandarakis
    From the encyclopedia
    Spironolactone →

    powerful topical and oral anti-androgen used mostly by women

    Cyproterone →

    a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

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    Studysummary This study reports that various antiandrogen therapies, including spironolactone and finasteride, effectively address hirsutism, acne, androgenic alopecia, and ovulatory dysfunction in hyperandrogenic women and are generally well tolerated.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    In 1998, antiandrogen therapy was identified as a promising treatment for androgenic disorders in women, which can cause social and psychological distress, as well as serious skin, reproductive, and metabolic abnormalities. Clinical studies demonstrated the effectiveness of various agents, including spironolactone, cyproterone acetate, flutamide, and finasteride, in treating hirsutism, acne, androgenic alopecia, and ovulatory dysfunction in hyperandrogenic women. Comparative clinical studies suggested that these agents, especially in low-dose regimens, were well tolerated and had potential for broader clinical use.
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