Skin Aging: Mechanisms, Evaluation, And Rejuvenation

This study reports that adipose mesenchymal stem cell-derived exosomes and platelet-rich plasma both improved the condition of photoaged facial skin, with no significant difference in effectiveness between the two treatments, potentially offering a quicker and less invasive option for patients.

In this study, researchers found that treating senescent human dermal papilla cells with dasatinib and quercetin improved their ability to regenerate hair follicles by depleting senescent cells and enhancing inductive potency, suggesting potential clinical applications for senolytic treatments in cell-based hair restoration therapies.

This study found that human umbilical cord mesenchymal stem cells (hUCMSCs) promoted hair regeneration in androgenetic alopecia model mice by activating Wnt/β-catenin signaling, enhancing hair follicle stem cell proliferation, and reducing dermal papilla cell apoptosis.

This review explores the complex interactions between epidermal stem cells and their environment, highlighting the critical roles of these cells in skin wound healing and tissue repair processes.

This review explores recent advancements in understanding how various physiological and psychological factors, such as stress and aging, influence epidermal stem cell populations, highlighting their importance in immune-related skin disorders and potential for clinical applications.

In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

In this study, NMN was found to reverse hair follicle atrophy, thinning, and sparsity in mice induced by DHT, and significantly decreased DHT-induced inflammation and oxidative stress in cultured human dermal papilla cells, enhancing hair growth-related markers.

This study highlights age and sex as key factors influencing scalp parameters, thereby affecting hair health and suggesting they should be considered in developing hair care strategies.

In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.

This article reviews the aging process of sebaceous glands, highlighting the role of intrinsic and extrinsic factors on their degradation and reporting no new clinical findings.

This study used single-cell RNA sequencing to create a detailed atlas of human scalp hair follicles and found that early-stage hair graying involves matrix hair progenitor depletion linked to P53 pathway activation.

In this study, metformin promoted hair follicle regeneration in vitro by enhancing the hair inductive capability of dermal cells, warranting further exploration for pattern hair loss treatment.

This study reports that hair follicle-derived mesenchymal stem cells significantly reduced hair loss and inflammation in alopecia areata models, suggesting a potential therapeutic approach.

This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.

This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.

This study found that activating autophagy with specific small molecules and drugs can stimulate hair growth by initiating the anagen phase in dormant hair follicles, suggesting a potential treatment for hair loss.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hair follicle stem cells inactive, and its removal leads to hair growth initiation in mice.

This study found that reduced cell cohesiveness in eccrine sweat gland outgrowths contributed to delayed wound healing in elderly skin compared to younger skin.

This study shows that inhibiting anti-apoptotic proteins BCL-W and BCL-XL can specifically induce apoptosis in senescent cells, suggesting a potential strategy for treating age-related pathologies.

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.

This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.

This study found that mice with a specific loss of DNA methyltransferase 1 showed uneven epidermal thickness, reduced hair regeneration, and progressive alopecia, emphasizing DNA methylation's role in stem cell homeostasis.

This study reports that 11β-HSD1 activity in human skin increases with age and photoexposure, potentially contributing to skin aging and the effects of glucocorticoids.

This review highlights recent findings on the importance of signalling pathways in sebaceous gland morphogenesis and differentiation, but reports no new clinical results.

In this study, researchers discovered that activating TERT in mouse skin epithelium triggers dormant hair follicle stem cells, leading to rapid hair growth, through a pathway independent of telomere extension.

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

The study found that reducing testosterone in male mice through castration or androgen antagonism significantly accelerated wound healing by decreasing inflammation, suggesting a potential therapeutic target for impaired healing in elderly men.