Unlocking the Therapeutic Potential of TRPV3: Insights into Thermosensation, Channel Modulation, and Skin Homeostasis

May 2024 in “ BioEssays ”

Jing Lei, Makoto Tominaga

TRPV3 thermosensation skin homeostasis keratinocytes TMEM79 hair growth skin barrier inflammation itching

TLDR TRPV3 is important for skin health and could be a target for treating skin diseases.

This review highlights the crucial role of the TRPV3 ion channel in warmth sensation and skin homeostasis, emphasizing its expression in skin keratinocytes. It discusses how TRPV3's membrane abundance, modulated by TMEM79, affects thermosensation and explores its electrophysiological and structural properties. While TRPV3's direct contribution to warmth sensation in vivo is debated, its involvement in skin physiology and pathology, including barrier formation, hair growth, inflammation, and itching, is significant. The review also considers TRPV3 as a potential therapeutic target for skin diseases, underscoring its diverse role in maintaining skin health.

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Unlocking the Therapeutic Potential of TRPV3: Insights into Thermosensation, Channel Modulation, and Skin Homeostasis

Research cited in this study

research TRPV3 Ion Channel: From Gene to Pharmacology

research Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

research Mechanisms of Proton Inhibition and Sensitization of the Cation Channel TRPV3

research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

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community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

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