Unlocking the Therapeutic Potential of TRPV3: Insights into Thermosensation, Channel Modulation, and Skin Homeostasis

The review discusses the role of TRPV3, a warmth-sensitive ion channel, in skin homeostasis and its potential as a therapeutic target. TRPV3 is expressed in skin keratinocytes and is involved in thermosensation, keratinocyte proliferation, wound healing, and hair morphogenesis. It is modulated by factors such as calcium, lipids, and protons, and its activation is linked to skin disorders like itch and inflammation. Structural studies have provided insights into its gating mechanisms, emphasizing the importance of lipid interactions. The interaction with TMEM79 is crucial for maintaining skin homeostasis. Further research is needed to fully understand TRPV3's functions and therapeutic potential.