Unlocking the Therapeutic Potential of TRPV3: Insights into Thermosensation, Channel Modulation, and Skin Homeostasis

    May 2024 in “ BioEssays ”
    Jing Lei, Makoto Tominaga
    Studysummary This review examined the role of the ion channel TRPV3 in warmth sensation and skin physiology, discussing controversies around its direct contribution to temperature perception, its involvement in skin health, and its potential as a therapeutic target for skin diseases.
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    Research cited in this study 6

    1. TRPV3 Ion Channel: From Gene to Pharmacology International Journal of Molecular Sciences · 2023
    2. Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole EMBO reports · 2021
    3. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    4. Mechanisms of Proton Inhibition and Sensitization of the Cation Channel TRPV3 The Journal of General Physiology · 2020
    5. Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes Journal of Investigative Dermatology · 2017
    6. Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011