Role of Transient Receptor Potential Vanilloid 4 Channel in Skin Physiology and Pathology

June 2020 in “ Sultan Qaboos University medical journal ”

Ammar Boudaka, Mallak Al-Yazeedi, Intisar Al‐Lawati

Transient Receptor Potential Vanilloid 4 TRPV4 keratinocytes melanocytes sensory neurons immune cells skin homeostasis pruritus inflammation carcinogenesis

Studysummary This review discusses the role of the TRPV4 channel in skin physiology and pathology, highlighting its potential as a therapeutic target for skin disorders, but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviewed the role of the Transient Receptor Potential Vanilloid 4 (TRPV4) channel in skin physiology and pathology. TRPV4, a non-selective cation channel, responded to temperature and various stimuli and was expressed in multiple organs, including the skin. In the skin, it was found in keratinocytes, melanocytes, sensory neurons, and immune cells, playing roles in skin homeostasis and sensation. Dysfunctional TRPV4 activity was linked to skin conditions like barrier compromise, pruritus, pain, inflammation, and carcinogenesis. The channel's pharmacologically-accessible sites made it a potential therapeutic target for skin disorders. The review summarized TRPV4's physiological and pathophysiological effects in the skin.

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