Localization of Mechanosensitive Channel TRPV4 in Mouse Skin

    November 2003 in “ Neuroscience Letters ”
    Makoto Suzuki, Yuko Watanabe, Yuki Oyama, Atsuko Mizuno, Eiji Kusano, Atsushi Hirao, Shigeo Ookawara
    TLDR TRPV4 helps sense pressure in mouse skin.
    The study investigated the localization of the TRPV4 channel in mouse skin, revealing its expression in both small and large dorsal root ganglia neurons. TRPV4 was found at cutaneous mechanosensory terminals, such as Meissner, Merkel, penicillate, and intraepidermal terminals, but not at hair follicle palisades. This distribution suggested that TRPV4 played a role in transmitting pressure sensation through A- and C-fibers, contributing to cutaneous mechanosensation.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Research

    1 / 1 results