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    Glossary SRD5A2 gene

    gene converts testosterone into potent androgen DHT

    The SRD5A2 gene provides instructions for making an enzyme called steroid 5-alpha reductase type 2. This enzyme is crucial for converting testosterone into dihydrotestosterone (DHT), a more potent androgen that plays a key role in the development of male characteristics and is also implicated in conditions like male pattern baldness and certain forms of alopecia.

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    Research 30 of 409

    1. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study Endocrine connections · 2019 · 8 citations
    2. Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population Postępy Dermatologii i Alergologii · 2018 · 3 citations
    3. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021 · 14 citations
    4. Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur Scientific reports · 2023
    5. Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances Plants · 2022 · 7 citations
    6. Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors Birth Defects Research · 2003 · 103 citations
    7. 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia International Journal of Cancer · 2006 · 57 citations
    8. Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer Endocrine Related Cancer · 2010 · 30 citations
    9. Rare and common genetic determinants of metabolic individuality and their effects on human health Nature Medicine · 2022 · 29 citations
    10. Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants Frontiers in Genetics · 2024 · 13 citations
    11. Identification of a Rare Variant in the <i>SRD5A2</i> Gene in Siblings With 46,XY Disorders of Sexual Development Case Reports in Genetics · 2025
    12. Adjuvant measures and genetic evaluations to improve results of hair transplantation Cellular and Molecular Biology · 2022
    13. Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology Medizinische Genetik · 2023
    14. Genetics of Polycystic Ovary Syndrome 2016 · 1 citations
    15. Investigations of 13 Genes in Non-Cicatricial Alopecia 2023
    16. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998 · 169 citations
    17. Analysis of genetic polymorphisms of steroid 5α-reductase type 1 and 2 genes in Korean men with androgenetic alopecia Journal of Dermatological Science · 2003 · 15 citations
    18. Study on genetic polymorphisms of androgen receptor gene and 5α-reductase genes of Han men with androgenetic alopecia in the Eastern China Chinese Journal of Dermatology · 2006
    19. Effects of Bioactive Composition in Oryza sativa L. cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells Agronomy · 2023 · 3 citations
    20. Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes European Journal of Endocrinology · 2024 · 1 citations
    21. Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement Genes · 2024
    22. Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia Medicina-lithuania · 2023
    23. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    24. The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals Brazilian Journal of Medical and Biological Research · 2003 · 17 citations
    25. Effects of finasteride on steroid production and gene expression in male fathead minnow (Pimephales promelas) and medaka (Oryzias latipes) 2026
    26. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    27. The slick hair coat locus maps to chromosome 20 in Senepol-derived cattle Animal Genetics · 2007 · 51 citations
    28. Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy Biomaterials · 2019 · 47 citations
    29. 5-α-Reductase type 2 deficiency: is there a genotype-phenotype correlation? A review Hormones · 2018 · 39 citations
    30. Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing Journal of Nanobiotechnology · 2022 · 7 citations