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This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

This study found that the Hy-Tissue Nanofat product isolates a significant number of proliferative nucleated cells and shows potential for regenerative medicine due to its rich content of adipose-derived stem cells and pluripotent MUSE cells.

This review discusses various mechanical isolation procedures for tissue-like stromal vascular fraction, such as the nanofat procedure, and highlights the need for controlled trials to assess their regenerative effectiveness.

This study found that nanostructured lipid carriers significantly improved the targeted delivery of latanoprost and minoxidil to pilosebaceous units in porcine skin, with latanoprost showing notably higher accumulation.

This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.

The study found that cyproterone acetate-loaded nanostructured lipid carriers, particularly those with a 300 nm diameter, improved skin penetration and targeted hair follicles more effectively than free cyproterone acetate.

This study found that resveratrol-loaded polymeric nanoparticles show promise as a pulmonary drug delivery system for lung cancer, reducing resveratrol's IC50 significantly in Calu 3 cells.

In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.

This review examines the advances in nanostructured lipid carriers for treating hyperpigmentation but presents no new clinical results; the authors highlight their potential benefits and applications.

This study developed a new finasteride release system using chitosan-based nanoniosomes, observing that 70% of the drug was released over ten days in vitro, suggesting potential for prostate cancer prevention.

In this study, blue light-irradiated nanovesicles derived from human adipose-derived stem cells enhanced dermal fibroblast proliferation and extracellular matrix synthesis, improving skin maintenance and hair follicle regeneration, suggesting a novel therapeutic strategy for skin and hair disorders.

This study found that in androgenetic alopecia mice, MNX@Arg-CLAVs, a novel nanovesicle platform containing minoxidil and conjugated linoleic acid, enhanced hair regeneration and reduced hair follicle aging more effectively and with less irritation compared to traditional minoxidil tincture.

This review explores the potential diagnostic and therapeutic applications of extracellular vesicles in treating various skin conditions but reports no new clinical study results.

This review summarizes a 15-year collaboration on the role of synaptic-like vesicles in mechanosensory nerve terminals and suggests potential therapeutic implications for conditions like hypertension and muscle spasticity.

In this study, the researchers developed a novasome vesicle carrying bovine placenta extract, which demonstrated superior hair growth effects in rats compared to traditional minoxidil and PE-loaded liposomes, and showed good stability and physical characteristics over 90 days at 4°C.

This study reports that a novel Nano-Structured Lipid Carrier system for delivering dutasteride may enhance its anticancer effects while reducing systemic side effects in clinical settings.

This review explores fundamental aspects of niosomes in drug delivery, including their structure, preparation methods, and factors influencing their formation, but it reports no new experimental results.

This research observed that nanoliposomes delivering a combination of bioactive peptides significantly promoted hair growth in vitro and in vivo by enhancing the proliferation and function of hair growth-targeted cells in C57BL/6 mice, suggesting a promising approach for treating androgenetic alopecia.

This study found that adipose stem cell-derived nanovesicles promoted dermal papilla cell proliferation, migration, and anti-apoptotic effects in vitro and enhanced hair follicle cycle progression in mice, primarily through activation of the β-catenin signaling pathway.

In this study, treatment with cell-derived nanovesicles from hair follicle mesenchymal stem cells improved photoaging signs in UVB-exposed mice and human dermal fibroblasts by reducing oxidative stress, enhancing cell proliferation, and promoting extracellular matrix production.

This study found that NIMP-R14-conjugated nanoparticles, loaded with roflumilast, effectively targeted neutrophils to reduce inflammation and improve symptoms in a mouse model of psoriasiform dermatitis, suggesting potential for targeted therapy in autoimmune skin diseases.

This study found that PPD-Lip@RES may effectively promote hair growth in models of telogen effluvium and androgenetic alopecia, suggesting its potential as a promising treatment strategy by addressing the underlying pathological and physiological processes of hair loss.

This study found that nanoethosomes containing Lidocaine showed effective skin penetration, suggesting they may be a suitable carrier for topical anesthetic delivery.

The study found that hybrid nanoparticles incorporating exosomes with cationic liposomes 2X3-DOPE significantly improved the delivery of both messenger RNA and small interfering RNA to rat cardiac mesenchymal stem cells in vitro, achieving up to 100% transfection efficiency for small interfering RNA.

In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.

This review discusses the applications and potential of microneedles loaded with extracellular vesicles for tissue regenerative repair and disease diagnosis, but does not report new experimental findings.

This study found that actively targeted AN2728-loaded nanocarriers reduced inflammation and improved skin condition in a mouse model of psoriasiform inflammation compared to free drug and non-targeted nanoparticles.

Nanofat injection is safe and effective for improving skin texture and patient satisfaction.

This study reported that ultrafine gelatin nanoparticles produced by a modified desolvation technique offer advantages for dermal drug delivery, including smaller particle size, higher drug loading, and faster release compared to traditional gelatin nanoparticles.

This review highlights recent advancements in lipid nanoparticle technology for delivering genetic material and treating various diseases, but notes challenges in manufacturing, stability, and safety evaluations.