Exosomes Facilitate mRNA and siRNA Delivery Using Cationic Liposomes 2X3-DOPE to Rat Heart Mesenchymal Cells In Vitro

    June 2025 in “ Medical academic journal ”
    Olesya Dovbysh, Vera V. Vysochinskaya, Nina V. Gavrilova … Yana Zabrodskaya
    Studysummary The study found that hybrid nanoparticles incorporating exosomes with cationic liposomes 2X3-DOPE significantly improved the delivery of both messenger RNA and small interfering RNA to rat cardiac mesenchymal stem cells in vitro, achieving up to 100% transfection efficiency for small interfering RNA.
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