Niosomes: A Novel Targeted Drug Delivery System

The document reviews the use of niosomes, a type of nanotechnology, in targeted drug delivery systems. Niosomes are produced by nonionic surfactants and can carry both hydrophilic and hydrophobic drugs due to their amphiphilic nature. Other compounds, like cholesterol, can be added to the niosomes to make the structure more rigid. The structure of niosomes can be affected by several variables, including the type of surfactant used, the preparation method, and the hydration temperature. In-silico tools are used to design drug delivery formulations, evaluating the physicochemical features of the formulation and its absorption, distribution, excretion, and metabolism (ADME) properties before synthesis. This process also investigates the interaction between the nano-carriers and specific targets. In-vitro and in-vivo experimentation is essential to validate these designs.