Strengthening the Cellular Function of Dermal Fibroblasts and Dermal Papilla Cells Using Nanovesicles Extracted from Stem Cells with Blue Light-Based Photobiomodulation Technology

    January 2025 in “ Biomaterials Science
    Jiyu Hyun, Sangyoon Lee, Jiseon An, You‐Bin Lee, Suk Ho Bhang
    The study explores the use of nanovesicles (NVs) derived from human adipose-derived stem cells (hADSCs) and enhanced by blue light-based photobiomodulation (PBM) to improve the function of human dermal fibroblasts (hDFs) and hair follicle dermal papilla cells (HFDPCs). These NVs, when irradiated with blue light, showed increased efficacy in promoting hDF proliferation, extracellular matrix synthesis, and HFDPC functionality, which are crucial for skin maintenance and hair follicle regeneration. This innovative approach offers a promising and safer therapeutic strategy for treating skin and hair disorders, such as alopecia, by enhancing cellular activities and regenerative capabilities.
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