Rejuvenating Senescent Hair Follicles: A Novel Conjugated Linoleic Acid Based Nanovesicle Approach to Treat Androgenic Alopecia

    November 2025 in “ Journal of Nanobiotechnology
    Yating Dong, Yingying Sun, Aojie Li, Yuxuan Yu, Wengkuan U, Hongjuan Zhang, Xuefei Zhang, Yihua Huang, HaiYan Hu
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    TLDR A new treatment using special nanovesicles with linoleic acid shows promise in improving hair growth and reducing irritation for hair loss.
    This study introduces a novel treatment for androgenetic alopecia (AGA) using conjugated linoleic acid (CLA) loaded into nanovesicles (Arg-CLAVs) to rejuvenate aging hair follicles. The research demonstrates that Arg-CLAVs can mitigate the effects of dihydrotestosterone (DHT) by reducing oxidative stress and improving the hair follicle environment. Furthermore, incorporating minoxidil (MNX) into these nanovesicles (MNX@Arg-CLAVs) enhanced hair growth and reduced skin irritation in AGA mice compared to traditional MNX treatments. This approach offers a promising strategy to improve the efficacy of current AGA therapies.
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