Rejuvenating Senescent Hair Follicles: A Novel Conjugated Linoleic Acid Based Nanovesicle Approach to Treat Androgenic Alopecia

This study addresses the limitations of current androgenetic alopecia (AGA) treatments by introducing a novel approach using conjugated linoleic acid (CLA)-loaded nanovesicles (Arg-CLAVs) to rejuvenate senescent hair follicles (HFs). The research highlights the role of dihydrotestosterone (DHT) in HF miniaturization and identifies CLA's anti-aging potential. Arg-CLAVs counteract DHT-induced HF aging by reducing oxidative stress, modulating the MAPK-ERK signaling pathway, and enhancing the HF environment through angiogenesis and dermal papilla cell proliferation. The study further incorporates minoxidil (MNX) into the nanovesicles (MNX@Arg-CLAVs), demonstrating improved hair growth and reduced skin irritation in AGA mice compared to commercial MNX tincture. This innovative nanoplatform offers synergistic effects with existing treatments, presenting a promising advancement in AGA therapy.