Pulmonary Delivery of Resveratrol-Loaded Nanocomposite Microparticles to Treat Lung Cancer

The study investigated the use of resveratrol-loaded nanocomposite microparticles (NCMPs) for pulmonary delivery to treat lung cancer. Resveratrol was encapsulated in polymeric nanoparticles (NPs) with high efficiency and formulated into NCMPs suitable for inhalation. The NPs showed good cytocompatibility and significantly reduced the IC50 of resveratrol in lung cancer cells, indicating enhanced efficacy. The NCMPs had ideal aerodynamic properties for deep lung deposition and demonstrated a slow release profile. A novel polymer was also synthesized for potential ligand attachment. Overall, the results suggested that these NPs/NCMPs could be promising for lung cancer treatment.